Tuesday, February 27, 2024

The millionth vet joined the database on the afternoon of Nov. 11. Employees who had waited a dozen years for this moment wept.

As the goal approached, the department had started an intensive email campaign, encouraging vets to sign up online or at V.A. medical centers. In the few weeks building up to the millionth vet, what had been a few hundred enrollees a day turned into thousands. The department created a ticker, which it posted online, showing the numbers.

“This is a gift to the world,” said Denis McDonough, secretary of veterans affairs.

The V.A. will continue to enroll more vets to the database, but this was a symbolic moment.

For years, researchers have been building large databases for genetic research. Using them they have found, for example, genes that appear to confer resistance to dementia and ones that most likely contribute to obesity. The discoveries provide paths to understanding these diseases and developing treatments.

There are other large genetic databases, but they have mostly been built in Europe and include few minorities. The V.A. says its database offers a more diverse population: 175,000 people with African ancestry and 80,000 Hispanics joined the Million Veteran Program. The database also includes 100,000 women.

“It’s a massive investment and scientific opportunity,” said Dr. Amit V. Khera, a genetic researcher at Massachusetts General Hospital. He is not a V.A. researcher, but he has used the data through collaborations with researchers who are affiliated with the department.

As the database acquired participants, about 600 V.A. researchers registered to use it. The result so far has been more than 350 papers on diseases and disorders, including post-traumatic stress disorder, heart disease, high blood pressure and nonalcoholic liver disease.

For example, said Dr. Sumitra Muralidhar, director of the Million Veteran Program, researchers found genes linked to having flashbacks of traumatic events, a feature of post-traumatic stress. Now, Dr. Muralidhar said, investigators can study those genes and the role they play, which may help in developing treatments for PTSD.

The department also says it is being mindful of patient privacy. Although researchers can examine genetic and other data and links to medical records, fewer than 10 people at the V.A. have the links that tie records to individuals. Those records, Dr. Muralidhar said, are held at a facility in Boston that is “heavily secured.”

In 2019, a nurse at a V.A. hospital told Octavia Harris, 60, of San Antonio, about the Million Veteran Program. She signed up and said participating was a chance to help other vets and to help herself.

Ms. Harris, who retired from the Navy in 2012 after 30 years of service, said three conditions run in her family — diabetes, high blood pressure and arthritis. She is hoping that with her genetic and health information added to that of so many others, researchers will make useful discoveries.

In her family, Ms. Harris said, people died young.

“We haven’t lived beyond the age of 70,” she said. “I want to go past 70.”

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